Protein Details: Voltage-gated sodium channel subunit beta-3
Protein ID
ICDB_Pro_0897
Protein Name
Voltage-gated sodium channel subunit beta-3
Gene Name
SCN3B
Organism
Bos taurus (Bovine)
Length
215 amino acids
AlphaFoldDB
AF-Q2KI11-F1-model_v4.pdb
Function
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
Sequence
MPAFNRLFPLASLLLILWVGVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
mature myelinated axons
DOI ID
RefSeq
NP_001039960.1